Macromedia's Flash has a scripting language called ActionScript. It can interact with other languages like PHP/MySQL to use data from a database and show graphs, etc. But once you burn your video to mpeg2 for DVD use, (VOB) you no longer have that ability to read a database even though you could have a database right on the same DVD.
You could use Macromedia's Director and probably interface with VB and a database like Access or an Xbase .dbf table, but not as an mpeg2.
As for "interactivity", obviously, when used on the Web, interactivity is a snap - but on a DVD, you're limited to menus, although you can get very creative with invisible buttons, etc., you are severely limited.
The new Blu-Ray and HD-DVD specs offer much more in the way of creativity and interctivity when it comes to burning DVD videos, but I haven't studied up on that just yet.