You don't specify if you're talking about the ceremony or the reception. They're really two completely different animals.
I've shot dozens of weddings and seldom (if ever) had to break the 180 rule for a ceremony.
First, I don't think of the 180 line as going down the aisle or running across the wedding party. Rather, it usually runs from one corner of the church to the bride (after all, she's the one you have to make happy so shoot from the groom side and focus towards her.)
I wish I could draw this out but imagine your standard wedding setup - if you're in the back of the church you can shoot from either side of the aisle as they enter (although groom side is preferable,) have a stationary camera (or a second camera operator) on the groom side of the church shooting towards the bride, a reverse angle camera behind the groom pointing back towards the couple showing the front of the bride, a centered up wide shot from the balcony, etc. Just think of the bride's side of the 180 as off limits. Shoot from the groom's side or the rear of the church and you'll be fine.
Weddings are surprisingly predictable. If you attend the rehearsal they're even more so. As a result, I almost never use handheld during a ceremony so there's little chance I'll 'accidentally' break the 180. Tripods during a ceremony are really mandatory.
I can manage two-three video cameras by myself during a ceremony plus as many stationary cameras as I feel the service needs for cutaways.
When working with a partner, I work two cameras from the back (a wide shot and a zoomed in close-up of the couple) while my partner mans one off to the groom's side getting close-ups and audience cutaways.
As for the reception, who cares? :-) Shoot the action wherever you can get it from whatever angle you can. I seldom try to edit receptions as a sequence. I usually edit them into a musical montage with key events mixed in here and there in a generally chronological order. People seem to really love it.
As for the predictability of the reception - make friends with the wedding planner, still photographer and the DJ. They'll usually know what's going to happen and when. Also, many weddings have a written agenda or rundown of events that will help you plan for what's coming up next.